Diabetic nephropathy: of mice and men.
Authors Breyer MD, Böttinger E, Brosius FC, Coffman TM, Fogo A, Harris RC, Heilig CW,
Sharma K
Submitted By Kumar Sharma on 2/8/2009
Status Published
Journal Advances in chronic kidney disease
Year 2005
Date Published 4/1/2005
Volume : Pages 12(2) : 128 - 145
PubMed Reference 15822049
Abstract Accumulating evidence supports intrinsic genetic susceptibility as an important
variable in the progression of diabetic nephropathy in people. Mice provide an
experimental platform of unparalleled power for dissecting the genetics of
mammalian diseases; however, phenotypic analysis of diabetic mice lags behind
that already established for humans. Standardized benchmarks of hyperglycemia,
albuminuria, and measurements of renal failure remain to be developed for
different inbred strains of mice. The most glaring deficiency has been the lack
of a diabetic mouse model that develops progressively worsening renal
insufficiency, the sine qua non of diabetic nephropathy in humans. Differences
in susceptibility of these inbred strains to complications of diabetes mellitus
provide a possible avenue to dissect the genetic basis of diabetic nephropathy;
however, the identification of those strains and/or mutants most susceptible to
renal injury from diabetes mellitus is lacking. Identification of a mouse model
that faithfully mirrors the pathogenesis of DN in humans will undoubtedly
facilitate the development of new diagnostic and therapeutic interventions.


Investigators with authorship
NameInstitution
Matthew BreyerEli Lilly and Company
Frank BrosiusUniversity of Arizona
Thomas CoffmanDuke University Medical Center
Raymond HarrisVanderbilt University
Kumar SharmaUniversity of California San Diego

Complications