Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic
Authors Bugger H, Abel ED.
Submitted By E. Dale Abel on 12/19/2008
Status Published
Journal Clinical science
Year 2008
Date Published 3/1/2008
Volume : Pages 114 : 195 - 210
PubMed Reference 18184113
Abstract The metabolic syndrome represents a cluster of abnormalities, including obesity,
insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk
of developing cardiovascular diseases, such as coronary artery disease and heart
failure. The heart failure risk is increased even after adjusting for coronary
artery disease and hypertension, and evidence is emerging that changes in
cardiac energy metabolism might contribute to the development of contractile
dysfunction. Recent findings suggest that myocardial mitochondrial dysfunction
may play an important role in the pathogenesis of cardiac contractile
dysfunction in obesity, insulin resistance and Type 2 diabetes. This review will
discuss potential molecular mechanisms for these mitochondrial abnormalities

Investigators with authorship
E. Dale AbelUniversity of Iowa