Cardiac Remodeling in Obesity
Authors Abel ED, Litwin SE, Sweeney G
Submitted By E. Dale Abel on 12/19/2008
Status Published
Journal Physiological reviews
Year 2008
Date Published 4/1/2008
Volume : Pages 88 : 389 - 419
PubMed Reference 18391168
Abstract The dramatic increase in the prevalence of obesity and its strong association
with cardiovascular disease have resulted in unprecedented interest in
understanding the effects of obesity on the cardiovascular system. A consistent,
but puzzling clinical observation is that obesity confers an increased
susceptibility to the development of cardiac disease, while at the same time
affording protection against subsequent mortality (termed the obesity paradox).
In this review we focus on evidence available from human and animal model
studies and summarize the ways in which obesity can influence structure and
function of the heart. We also review current hypotheses regarding mechanisms
linking obesity and various aspects of cardiac remodeling. There is currently
great interest in the role of adipokines, factors secreted from adipose tissue,
and their role in the numerous cardiovascular complications of obesity. Here we
focus on the role of leptin and the emerging promise of adiponectin as a
cardioprotective agent. The challenge of understanding the association between
obesity and heart failure is complicated by the multifaceted interplay between
various hemodynamic, metabolic, and other physiological factors that ultimately
impact the myocardium. Furthermore, the end result of obesity-associated changes
in the myocardial structure and function may vary at distinct stages in the
progression of remodeling, may depend on the individual pathophysiology of heart
failure, and may even remain undetected for decades before clinical
manifestation. Here we summarize our current knowledge of this complex yet
intriguing topic.

Investigators with authorship
E. Dale AbelUniversity of Iowa


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