Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics
in a type 1 diabetes model.
Authors Østergaard JA, Bjerre M, RamachandraRao SP, Sharma K, Nyengaard JR, Hansen TK,
Thiel S, Flyvbjerg A
Submitted By Kumar Sharma on 10/31/2012
Status Published
Journal Experimental diabetes research
Year 2012
Date Published 6/1/2012
Volume : Pages 2012 : 678381
PubMed Reference 22645604
Abstract BACKGROUND. Mannan-binding lectin (MBL) is involved in the development of
diabetic nephropathy. MBL is a part of the innate immune system where it can
activate the complement system. Serum MBL level predicts later renal impairment
in diabetes patients. Direct involvement of MBL in the development of diabetic
kidney disease is observed in one animal strain. However, this involvement may
differ among the animal strains. We thus examined the impact of the genetic
background on the role of MBL in diabetic nephropathy.

Investigators with authorship
Kumar SharmaUniversity of California San Diego