Diabetic neuropathy: clinical manifestations and current treatments.
Authors Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL
Submitted By Eva Feldman on 10/31/2012
Status Published
Journal Lancet neurology
Year 2012
Date Published 6/1/2012
Volume : Pages 11 : 521 - 534
PubMed Reference 22608666
Abstract Diabetic peripheral neuropathy is a prevalent, disabling disorder. The most
common manifestation is distal symmetrical polyneuropathy (DSP), but many
patterns of nerve injury can occur. Currently, the only effective treatments are
glucose control and pain management. While glucose control substantially
decreases the development of neuropathy in those with type 1 diabetes, the
effect is probably much smaller in those with type 2 diabetes. Evidence supports
the use of specific anticonvulsants and antidepressants for pain management in
patients with diabetic peripheral neuropathy. However, the lack of
disease-modifying therapies for diabetic DSP makes the identification of new
modifiable risk factors essential. Growing evidence supports an association
between components of the metabolic syndrome, including prediabetes, and
neuropathy. Studies are needed to further explore this association, which has
implications for the development of new treatments for this common disorder.

Investigators with authorship
Eva FeldmanUniversity of Michigan