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Protocols & Methods
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IMPC / KOMP Data
Podocyte specific knock out of selenoproteins does not enhance nephropathy in
streptozotocin diabetic C57BL/6 mice.
Blauwkamp MN, Yu J, Schin MA, Burke KA, Berry MJ, Carlson BA, Brosius FC, Koenig
Frank Brosius on 10/31/2012
Volume : Pages
9 : 7
Selenoproteins contain selenocysteine (Sec), commonly considered the 21st
genetically encoded amino acid. Many selenoproteins, such as the glutathione
peroxidases and thioredoxin reductases, protect cells against oxidative stress
by functioning as antioxidants and/or through their roles in the maintenance of
intracellular redox balance. Since oxidative stress has been implicated in the
pathogenesis of diabetic nephropathy, we hypothesized that selenoproteins
protect against this complication of diabetes.
Investigators with authorship
University of Arizona
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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