Podocyte specific knock out of selenoproteins does not enhance nephropathy in
streptozotocin diabetic C57BL/6 mice.
Authors Blauwkamp MN, Yu J, Schin MA, Burke KA, Berry MJ, Carlson BA, Brosius FC, Koenig
Submitted By Frank Brosius on 10/31/2012
Status Published
Journal BMC nephrology
Year 2008
Date Published 3/1/2007
Volume : Pages 9 : 7
PubMed Reference 18647412
Abstract Selenoproteins contain selenocysteine (Sec), commonly considered the 21st
genetically encoded amino acid. Many selenoproteins, such as the glutathione
peroxidases and thioredoxin reductases, protect cells against oxidative stress
by functioning as antioxidants and/or through their roles in the maintenance of
intracellular redox balance. Since oxidative stress has been implicated in the
pathogenesis of diabetic nephropathy, we hypothesized that selenoproteins
protect against this complication of diabetes.

Investigators with authorship
Frank BrosiusUniversity of Arizona