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Sugar, sex, and TGF-ß in diabetic nephropathy.
Diamond-Stanic MK, You YH, Sharma K
Kumar Sharma on 10/31/2012
Seminars in nephrology
Volume : Pages
32 : 261 - 268
TGF-ß is well known to play a critical role in diabetic kidney disease, and
ongoing clinical studies are testing the potential therapeutic promise of
inhibiting TGF-ß production and action. An aspect of TGF-ß action that has not
received much attention is its potential role in explaining sex-related
proclivity for kidney disease. In this review, we discuss recent studies linking
TGF-ß signaling to sex-related effects in diabetic kidney disease and suggest
targets for future studies.
Investigators with authorship
University of California San Diego
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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