Mouse Models of Diabetic Nephropathy
Authors MATTHEW D. BREYER, ERWIN BÖTTINGER, FRANK C. BROSIUS, III, THOMAS M. COFFMAN,
RAYMOND C. HARRIS, CHARLES W. HEILIG, AND KUMAR SHARMA (FOR THE AMDCC)
Submitted By Matthew Breyer on 8/4/2004
Status Published
Journal Journal of the American Society of Nephrology : JASN
Year 2005
Date Published 1/1/2005
Volume : Pages 16 : 27 - 45
PubMed Reference 15563560
Abstract : Mice provide an experimental model of unparalleled flexibility for studying
mammalian diseases, including diabetic nephropathy. Inbred strains of mice
exhibit substantial differences in the renal effects of diabetes mellitus. Much
remains to be established regarding the course of diabetic nephropathy in this
species and defining those strains and/or mutants most susceptible to renal
injury from diabetes mellitus. It will be especially important to determine
whether renal function declines in any of these mouse models of diabetic
nephropathy. Technical refinements in the measurement of plasma creatinine,
glomerular filtration rate, and uniform reporting of albuminuria and
histopathology, should facilitate progress in this field and allow better
comparisons of results obtained by different laboratories. Together with the
unique genetic reagents available in mice, the identification of a mouse model
of diabetic nephropathy that closely mirrors human disease will significantly
enhance our understanding of and accelerate our progress towards a treatment for
this disease.


Investigators with authorship
NameInstitution
Erwin BottingerMount Sinai School of Medicine
Matthew BreyerEli Lilly and Company
Frank BrosiusUniversity of Arizona
Thomas CoffmanDuke University Medical Center
Raymond HarrisVanderbilt University
Kumar SharmaUniversity of California San Diego

Complications