Diabetic kidney disease in the db/db mouse
Authors Kumar Sharma, Peter McCue, and Stephen R. Dunn
Submitted By Kumar Sharma on 6/9/2003
Status Published
Journal American journal of physiology. Renal physiology
Year 2003
Date Published 6/1/2003
Volume : Pages 284 : F1138 - F1144
PubMed Reference 12736165
Abstract Diabetic nephropathy is increasing in incidence and is now the number one cause
of end-stage renal disease in the industrialized world. To gain insight into the
genetic susceptibility and pathophysiology of diabetic nephropathy, an
appropriate mouse model of diabetic nephropathy would be critical. A large
number of mouse models of diabetes have been identified and their kidney disease
characterized to various degrees. Perhaps the best characterized and most
intensively investigated model is the db/db mouse. Because this model appears to
exhibit the most consistent and robust increase in albuminuria and mesangial
matrix expansion, it has been used as a model of progressive diabetic renal
disease. In this review, we present the findings from various studies on the
renal pathology of the db/db mouse model of diabetes in the context of human
diabetic nephropathy. Furthermore, we discuss shortfalls of assessing functional
renal disease in mouse models of diabetic kidney disease.

Investigators with authorship
Kumar SharmaUniversity of California San Diego