| Authors |
Blair YA, Doherty L, Temprosa M, Pop-Busui R, Gadde KM, Singh P, Owora AH,
Wessells H, Sarma AV,
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| Submitted By |
Submitted Externally on 4/25/2024 |
| Status |
Published |
| Journal |
Journal of diabetes and its complications |
| Year |
2024 |
| Date Published |
2/1/2024 |
| Volume : Pages |
38 : 108669 |
| PubMed Reference |
38219334 |
| Abstract |
To determine burden and identify correlates of erectile dysfunction (ED) among
men with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes
Prevention Program (DPP) Outcomes Study (DPPOS)., The 2017 DPPOS visit included
administration of the International Index of Erectile Function. Of 648 male
participants, 88 % (n = 568) completed the survey. Associations between
sociodemographic, behavioral, clinical, and glycemic measures at time of ED
assessment, and ED were examined using multivariable logistic regression models
in men with PreD and T2D separately., Overall, 218 (38 %) men met ED criteria.
Prevalence was similar in men with PreD (41 %) and T2D (37 %) (p = 0.4). In all
men, age (p < 0.001) increased odds of ED. Among men with PreD, those assigned
to intensive lifestyle intervention (ILS), but not metformin, had decreased odds
of ED compared with the placebo group (OR = 0.35, 95 % CI = 0.13, 0.94).
Non-Hispanic White race was associated with increased odds of ED compared with
other races (OR = 4.3; 95 % CI = 1.92, 9.65). Among men with T2D, ED risk did
not differ by DPP treatment assignment; however, individuals with metabolic
syndrome defined by National Cholesterol Education Program criteria, had
increased odds of ED (OR = 1.85, 95 % CI = 1.14, 3.01), as did individuals with
depression (OR = 2.05; 95 % CI = 1.10, 3.79)., ED is prevalent in men with PreD
and T2D. Our finding of reduced odds of ED in men randomized to ILS and with
PreD suggests a potential opportunity for risk mitigation in the prediabetes
interval. In men who have progressed to T2D, metabolic factors appear to be
associated with ED.
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