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The Rogosin Institute
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Nephron progenitor culture technology for ex vivo nephrogenesis
Diabetes strongly predisposes to chronic kidney disease, which afflicts approximately 10% of the adult population of the US. Because nephrogenesis is limited to the fetal period, severely damaged nephrons cannot be replaced in the adult human. Chronic kidney disease patients who do no retain sufficient functional kidney mass to sustain physiological function therefore require lifelong renal replacement therapy. Dialysis filters excess urea from the blood, but does not provide all of the physiological functions of the kidney, and a kidney transplant is often required as functional renal mass decreases. However, the demand for kidney transplants far exceeds availability. Technology for de novo nephrogenesis would enable therapeutic replacement of damaged kidney tissue, and would also provide human tissue with which we could study kidney development and the origins of kidney disease. We propose to systematic develop a procedure for propagation of pure nephron progenitor cells from mouse and human that can be used for bioengineering and engraftment studies. This project aims to provide a highly accessible method that will accelerate research on regenerative therapies for chronic kidney disease.
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Nephron progenitor culture technology for ex vivo nephrogenesis (Oxburgh, Leif)
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Year: 2018; Items: 1
Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney.
Muthukrishnan SD, Ryzhov S, Karolak M, Oxburgh L
Disease models & mechanisms
, 2018 (11)
Year: 2015; Items: 1
p53 Enables metabolic fitness and self-renewal of nephron progenitor cells.
Li Y, Liu J, Li W, Brown A, Baddoo M, Li M, Carroll T, Oxburgh L, Feng Y, Saifudeen Z
Development (Cambridge, England)
, 2015 (142), 1228 - 41
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The DiaComp Steering Committee is the governing body of the consortium. The principle function of this committee is to guide the scientific direction of the consortium. This is accomplished by creating various subcommittees necessary to advance the scientific goals and providing guidance to the broader complications research community. Policies for the consortium are developed through consultation with the
External Evaluation Committee
The DiaComp Nephropathy Committee has the principal function of furthering the mission of the consortium with regard to diabetic kidney disease.
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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