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DiaComp Funded Abstracts

Program Application Abstract
Potential anti-­platelet benefits of ?-­3 or ?-­6 fatty acid supplementation in patients with T2DM
Jones, Taylor   (University of Michigan-Ann Arbor)
Platelets exhibit hyperactive characteristics in type II diabetes mellitus patients and 65% of deaths in T2DM patients are due to thrombosis and stroke. Additionally, post menopausal females are more susceptible to thrombosis and stroke. To prevent unwanted vessel blockage, fatty acid supplements such as ?-­3 or ?-­6 are often recommended for individuals being treated for T2DM;; however, the underlying mechanism of protection afforded by these lipid products remains unclear. In order to study this mechanism, 41 post-­menopausal women with T2DM and 45 healthy post-­menopausal were enrolled in a double blind randomized crossover longitudinal study. The study involves two dietary supplements, primrose oil (?-­6: DGLA) and fish oil (?-­3: DHA/EPA), given for two month periods, each followed by two week washout periods. This study investigates the potential protective effects of fatty acid supplementation through inhibition of platelet activation. Oxidized fatty acids are known to play both a pro-­ and anti-­thrombotic effect on platelets depending on the fatty acid. Essential fatty acids such as omega-­3 (DHA/EPA) and omega-­6 (DGLA) appear to be protective, but the underlying mechanisms have not been fully elucidated as well as their true protection from thrombosis. We hypothesize that altering the fatty acid content in the platelet with ?-­3 and ?-­6 supplementation will be protective against unwanted platelet activation and thrombosis in patients with T2DM. Platelet reactivity in response to agonist stimulation was evaluated for each of the five blood draws via several measurements including aggregation, ?-­granule release, dense-­granule release, ?IIb?3 activation, RAP-­1 activation, and intracellular Ca2+ release. This is an ongoing study and the data will be analyzed at the conclusion of all diabetic and healthy blood draws. We hope to determine whether or not dietary supplementation with either ?-­3 or ?-­6 fatty acids is an alternative approach to limit unwanted platelet activation and thrombus formation in T2DM patients.