B6.129-Apoetm3(APOE*4)Mae Ldlrtm1(LDLR)Mae/J

These mice contain a mutation designed to replace gene function of endogenous mouse Apoe with the human apoE4 isoform. They also contain a mutation designed to replace gene function of endogenous mouse Ldlr with human LDLR. Mice homozygous for Apoe4 and heterozygous for Ldlrh (Apoe4/4Ldlrh/+) are viable and fertile. The half-life of Ldlr mRNA is elevated in the liver due to a more stable 3'UTR. Apoe4/4Ldlrh/+ exhibit severe atherosclerosis and a lower plasma lipid level (presumably due to increased Ldlr metabolism in the liver). These mice may be useful to identify the roles human lipoprotein metabolism related genes in diabetic dyslipidemia and vascular complications.


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