BKS.Cg-Dock7m +/+ Leprdb

Mice homozygous for the diabetes spontaneous mutation (Leprdb) become identifiably obese around three to four weeks of age. Elevations of plasma insulin begin at 10 to 14 days and of blood sugar at four to eight weeks. Homozygous mutant mice are polyphagic, polydipsic, and polyuric. The course of the disease is markedly influenced by genetic background. A number of features are observed on the C57BLKS background, including an uncontrolled rise in blood sugar, severe depletion of the insulin-producing beta-cells of the pancreatic islets, and death by 10 months of age. Exogenous insulin fails to control blood glucose levels and gluconeogenic enzyme activity increases. Peripheral neuropathy and myocardial disease are seen in C57BLKS Leprdb homozygotes. Wound healing is delayed and metabolic efficiency is increased. Although normal in body weight, blood glucose, and plasma insulin, heterozygotes (Leprdb/+) also have increased metabolic efficiency and can survive a prolonged fast longer than controls. Experiments involving destruction of the ventromedial nucleus of the hypothalamus suggest that Leprdb may cause a defect in the hypothalamus. Steroid sulfotransferase enzymes, aberrantly expressed in diabetic mice, interact with the Leprdb mutation as modifiers of gender differences in obesity-induced diabetes susceptibility. Because of the sterility of Leprdb homozygotes, misty has been incorporated into stocks for maintenance of the diabetes mutation. The repulsion double heterozygote (Leprdb +/+ Dock7m) facilitates identification of heterozygotes for breeding, while the coupling double heterozygote, (Leprdb Dock7m/+ +) allows identification of homozygotes before the onset of clinical symptoms.


Phenotyped ForOther Resources
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No DataNo DataNo DataData AvailableNo DataNo Data   


Data (.csv filetype)

W rodent (g)

SeriesSexNAvgSD
BKS.Cg-Dock7m +/+ LeprdbBoth7136.8410.78
 Male7136.8410.78
Avg = 40.14
Std = 10.74
N = 45
Age = 24 Avg = 26.4
Std = 0.81
N = 5
Age = 20 Avg = 32.24
Std = 8.69
N = 21
Age = 12 Avg = 40.14
Std = 10.74
N = 45
Age = 24 Avg = 26.4
Std = 0.81
N = 5
Age = 20 Avg = 32.24
Std = 8.69
N = 21
Age = 12










Neuropathy Validation
IENF (num/mm)LC (num/mm)MAD (μm)MFPHPAT (sec)sciatic motor CV (m/s)SNP (num/mm)sural NCV (m/s)TFAT (sec)LengthED (mm)
33.92No DataNo DataNo Data3.0436.14No Data19.414.80No Data