FVB/NJ

FVB/NJ was inbred for the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection. Compared to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE. Despite having the H2q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis. This resistance stems from coding polymorphisms in Tcra-V11.1 and a genomic deletion of some Tcrb-V genes that includes Tcrb-V8.2. FVB/NJ have higher than average activity, anxiety, and basal body temperature, low stress-induced hyperthermia, and are homozygous for the Pde6brd1 allele, which results in early onset retinal degeneration. Although FVB/N typically do not develop spontaneous tumors, they are highly susceptible to chemically induced squamous cell carcinomas with a high rate of malignant conversion from papilloma to carcinoma.


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
FVB/NJBoth117192.7643.39
 Female72191.6846.47
 Male45194.4937.87
Avg = 247.93
Std = 75.47
N = 15
Age = 26 Avg = 175.25
Std = 21.67
N = 16
Age = 24 Avg = 190.62
Std = 30.94
N = 16
Age = 20 Avg = 163.56
Std = 21.36
N = 16
Age = 16 Avg = 187.31
Std = 12.47
N = 16
Age = 12 Avg = 192.69
Std = 21.53
N = 16
Age = 8 Avg = 225
Std = 41.51
N = 6
Age = 5 Avg = 183.31
Std = 27.4
N = 16
Age = 4 Avg = 247.93
Std = 75.47
N = 15
Age = 26 Avg = 175.25
Std = 21.67
N = 16
Age = 24 Avg = 190.62
Std = 30.94
N = 16
Age = 20 Avg = 163.56
Std = 21.36
N = 16
Age = 16 Avg = 187.31
Std = 12.47
N = 16
Age = 12 Avg = 192.69
Std = 21.53
N = 16
Age = 8 Avg = 225
Std = 41.51
N = 6
Age = 5 Avg = 183.31
Std = 27.4
N = 16
Age = 4

insulin, plasma (pg/ml)

SeriesSexNAvgSD
FVB/NJBoth541359.13805.46
 Female33982.61455.29
 Male211950.81877.30
Avg = 1108.94
Std = 906
N = 16
Age = 24 Avg = 1391.19
Std = 435.8
N = 16
Age = 16 Avg = 1554.38
Std = 998.16
N = 16
Age = 8 Avg = 1420.17
Std = 460
N = 6
Age = 5 Avg = 1108.94
Std = 906
N = 16
Age = 24 Avg = 1391.19
Std = 435.8
N = 16
Age = 16 Avg = 1554.38
Std = 998.16
N = 16
Age = 8 Avg = 1420.17
Std = 460
N = 6
Age = 5

W rodent (g)

SeriesSexNAvgSD
FVB/NJBoth3124.274.41
 Female2122.323.06
 Male1028.373.98
Avg = 34.2
Std = 0
N = 1
Age = 26 Avg = 25.4
Std = 2.3
N = 2
Age = 24 Avg = 23.8
Std = 1.6
N = 2
Age = 22 Avg = 24.33
Std = 3.42
N = 12
Age = 20 Avg = 28.05
Std = 0.75
N = 2
Age = 18 Avg = 26.3
Std = 5.1
N = 3
Age = 16 Avg = 22.75
Std = 0.75
N = 2
Age = 14 Avg = 29.2
Std = 0
N = 1
Age = 12 Avg = 19.68
Std = 3.41
N = 6
Age = 5 Avg = 34.2
Std = 0
N = 1
Age = 26 Avg = 25.4
Std = 2.3
N = 2
Age = 24 Avg = 23.8
Std = 1.6
N = 2
Age = 22 Avg = 24.33
Std = 3.42
N = 12
Age = 20 Avg = 28.05
Std = 0.75
N = 2
Age = 18 Avg = 26.3
Std = 5.1
N = 3
Age = 16 Avg = 22.75
Std = 0.75
N = 2
Age = 14 Avg = 29.2
Std = 0
N = 1
Age = 12 Avg = 19.68
Std = 3.41
N = 6
Age = 5

fat body mass (g)

SeriesSexNAvgSD
FVB/NJBoth125.411.06
 Female64.830.47
 Male65.981.17
Avg = 5.41
Std = 1.06
N = 12

lean body mass (g)

SeriesSexNAvgSD
FVB/NJBoth1219.673.73
 Female616.080.83
 Male623.251.21
Avg = 19.67
Std = 3.73
N = 12

%BF (rodent) (%)

SeriesSexNAvgSD
FVB/NJBoth1221.682.52
 Female623.001.48
 Male620.352.64
Avg = 21.68
Std = 2.52
N = 12