DBA/1LacJ

Historical reports indicate DBA/1J and DBA/1LacJ mice immunized with type II collagen develop a severe polyarthritis mediated by an autoimmune response. Recent in-house studies suggest that the response to collagen induction in the DBA/1LacJ strain is not as robust as indicated by earlier studies. Arthritis models such as B10.RIII-H2r H2-T18b/(71NS)SnJ (Stock No. 000457) and BUB/BnJ (Stock No. 000653) can be used as alternatives to DBA/1LacJ. Similar to the human condition, mice with collagen-induced arthritis display synovitis and erosions of cartilage and bone. In addition, susceptibility in both humans and mice is linked to the expression of specific MHC class II molecules. DBA/1 mice show a low susceptibility to developing atherosclerotic aortic lesions (20 to 350 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat).


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Data (.csv filetype)

W rodent (g)

SeriesSexNAvgSD
DBA/1LacJBoth2823.031.50
 Male2823.031.50
Avg = 23.68
Std = 1.53
N = 7
Age = 24 Avg = 22.88
Std = 1.51
N = 7
Age = 20 Avg = 23.1
Std = 1.36
N = 7
Age = 14 Avg = 22.49
Std = 1.36
N = 7
Age = 12 Avg = 23.68
Std = 1.53
N = 7
Age = 24 Avg = 22.88
Std = 1.51
N = 7
Age = 20 Avg = 23.1
Std = 1.36
N = 7
Age = 14 Avg = 22.49
Std = 1.36
N = 7
Age = 12