B6.129P2-Apoetm1Unc/J

Strain Development The Apoetm1Unc mutant strain was developed in the laboratory of Dr. Nobuyo Maeda at The University of North Carolina at Chapel Hill. The 129-derived E14Tg2a ES cell line was used. The plasmid used is designated as pNMC109 and the founder line is T-89 in the primary reference. The C57BL/6J strain was produced by backcrossing the Apoetm1Unc mutation 10 times to C57BL/6J mice. Previously mice backcrossed 6 times (N6) to C57BL/6J mice were distributed solely. Mice from the N6 generation are homozygous for pink-eyed dilution p giving them pink eyes and a silver coat color. The E14Tg2a ES cell line carries this recessive mutation which remains linked to the targeted Apoe gene on Chromosome 7 at this backcross generation. Mice from the N6 colony are no longer available for distribution.


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
B6.129P2-Apoetm1Unc/JBoth102163.4335.93
 Female45154.6733.18
 Male57170.3536.50
Avg = 162.8
Std = 28.36
N = 15
Age = 16 Avg = 154.67
Std = 26.47
N = 15
Age = 12 Avg = 161.53
Std = 38.98
N = 15
Age = 8 Avg = 178.78
Std = 36.09
N = 27
Age = 6 Avg = 155.27
Std = 37.22
N = 30
Age = 4 Avg = 162.8
Std = 28.36
N = 15
Age = 16 Avg = 154.67
Std = 26.47
N = 15
Age = 12 Avg = 161.53
Std = 38.98
N = 15
Age = 8 Avg = 178.78
Std = 36.09
N = 27
Age = 6 Avg = 155.27
Std = 37.22
N = 30
Age = 4

insulin, plasma (pg/ml)

SeriesSexNAvgSD
B6.129P2-Apoetm1Unc/JBoth291380.861010.57
 Female131277.151010.75
 Male161465.131002.55
Avg = 1380.86
Std = 1010.57
N = 29

W rodent (g)

SeriesSexNAvgSD
B6.129P2-Apoetm1Unc/JBoth26824.334.45
 Female6721.044.19
 Male20125.423.98
Avg = 26.03
Std = 3.26
N = 19
Age = 24 Avg = 24.53
Std = 2.8
N = 23
Age = 20 Avg = 24.44
Std = 3.69
N = 39
Age = 16 Avg = 24.17
Std = 3.88
N = 15
Age = 14 Avg = 24.26
Std = 3.77
N = 38
Age = 12 Avg = 22.17
Std = 3.27
N = 15
Age = 10 Avg = 24.32
Std = 4.79
N = 39
Age = 8 Avg = 25.68
Std = 5.39
N = 44
Age = 6 Avg = 22.55
Std = 5.23
N = 36
Age = 4 Avg = 26.03
Std = 3.26
N = 19
Age = 24 Avg = 24.53
Std = 2.8
N = 23
Age = 20 Avg = 24.44
Std = 3.69
N = 39
Age = 16 Avg = 24.17
Std = 3.88
N = 15
Age = 14 Avg = 24.26
Std = 3.77
N = 38
Age = 12 Avg = 22.17
Std = 3.27
N = 15
Age = 10 Avg = 24.32
Std = 4.79
N = 39
Age = 8 Avg = 25.68
Std = 5.39
N = 44
Age = 6 Avg = 22.55
Std = 5.23
N = 36
Age = 4