B6.129S7-Ldlrtm1Her/J

Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals. Mice homozygous for the Ldlrtm1Her mutation have an elevated serum cholesterol level of 200-400 mg/dl and they have very high levels (>2,000 mg/dl) when fed a high fat diet. Normal serum cholesterol in the mouse is 80-100 mg/dl.


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
B6.129S7-Ldlrtm1Her/JBoth96172.6651.34
 Male96172.6651.34
Avg = 249.88
Std = 92.38
N = 8
Age = 26 Avg = 128
Std = 24.48
N = 8
Age = 24 Avg = 159.06
Std = 30.23
N = 16
Age = 20 Avg = 186.5
Std = 36.54
N = 16
Age = 16 Avg = 153.06
Std = 19.51
N = 16
Age = 12 Avg = 155.75
Std = 47.62
N = 16
Age = 8 Avg = 193.38
Std = 32.15
N = 13
Age = 6 Avg = 189.33
Std = 21.7
N = 3
Age = 4 Avg = 249.88
Std = 92.38
N = 8
Age = 26 Avg = 128
Std = 24.48
N = 8
Age = 24 Avg = 159.06
Std = 30.23
N = 16
Age = 20 Avg = 186.5
Std = 36.54
N = 16
Age = 16 Avg = 153.06
Std = 19.51
N = 16
Age = 12 Avg = 155.75
Std = 47.62
N = 16
Age = 8 Avg = 193.38
Std = 32.15
N = 13
Age = 6 Avg = 189.33
Std = 21.7
N = 3
Age = 4

insulin, plasma (pg/ml)

SeriesSexNAvgSD
B6.129S7-Ldlrtm1Her/JBoth221860.14748.37
 Male221860.14748.37
Avg = 2261.86
Std = 750.98
N = 7
Age = 24 Avg = 1904.88
Std = 774.55
N = 8
Age = 16 Avg = 1407.29
Std = 376.59
N = 7
Age = 8 Avg = 2261.86
Std = 750.98
N = 7
Age = 24 Avg = 1904.88
Std = 774.55
N = 8
Age = 16 Avg = 1407.29
Std = 376.59
N = 7
Age = 8

W rodent (g)

SeriesSexNAvgSD
B6.129S7-Ldlrtm1Her/JBoth9126.133.99
 Male9126.133.99
Avg = 28.72
Std = 2.03
N = 8
Age = 26 Avg = 30.1
Std = 2.04
N = 8
Age = 24 Avg = 28.74
Std = 1.51
N = 8
Age = 22 Avg = 29.17
Std = 2.51
N = 8
Age = 20 Avg = 27.84
Std = 2.03
N = 8
Age = 18 Avg = 27.59
Std = 2.01
N = 8
Age = 16 Avg = 26.49
Std = 1.96
N = 8
Age = 14 Avg = 25.35
Std = 1.83
N = 8
Age = 12 Avg = 23.9
Std = 1.76
N = 8
Age = 10 Avg = 22.9
Std = 1.91
N = 8
Age = 8 Avg = 21.04
Std = 1.79
N = 8
Age = 6 Avg = 14.3
Std = 1.37
N = 3
Age = 4 Avg = 28.72
Std = 2.03
N = 8
Age = 26 Avg = 30.1
Std = 2.04
N = 8
Age = 24 Avg = 28.74
Std = 1.51
N = 8
Age = 22 Avg = 29.17
Std = 2.51
N = 8
Age = 20 Avg = 27.84
Std = 2.03
N = 8
Age = 18 Avg = 27.59
Std = 2.01
N = 8
Age = 16 Avg = 26.49
Std = 1.96
N = 8
Age = 14 Avg = 25.35
Std = 1.83
N = 8
Age = 12 Avg = 23.9
Std = 1.76
N = 8
Age = 10 Avg = 22.9
Std = 1.91
N = 8
Age = 8 Avg = 21.04
Std = 1.79
N = 8
Age = 6 Avg = 14.3
Std = 1.37
N = 3
Age = 4

fat body mass (g)

SeriesSexNAvgSD
B6.129S7-Ldlrtm1Her/JBoth85.140.43
 Male85.140.43
Avg = 5.14
Std = 0.43
N = 8

lean body mass (g)

SeriesSexNAvgSD
B6.129S7-Ldlrtm1Her/JBoth821.501.63
 Male821.501.63
Avg = 21.5
Std = 1.63
N = 8

%BF (rodent) (%)

SeriesSexNAvgSD
B6.129S7-Ldlrtm1Her/JBoth819.260.90
 Male819.260.90
Avg = 19.26
Std = 0.9
N = 8