High-Resolution Taxonomic Characterization Reveals Novel Human Microbial Strains
with Potential as Risk Factors and Probiotics for Prediabetes and Type 2
Authors Hendricks SA, Vella CA, New DD, Aunjum A, Antush M, Geidl R, Andrews KR, Balemba
Submitted By Submitted Externally on 8/28/2023
Status Published
Journal Microorganisms
Year 2023
Date Published 3/1/2023
Volume : Pages 11 : Not Specified
PubMed Reference 36985331
Abstract Alterations in the composition of the gut microbiota is thought to play a key
role in causing type 2 diabetes, yet is not fully understood, especially at the
strain level. Here, we used long-read DNA sequencing technology of 16S-ITS-23S
rRNA genes for high-resolution characterization of gut microbiota in the
development of type 2 diabetes. Gut microbiota composition was characterized
from fecal DNA from 47 participants divided into 4 cohorts based on glycemic
control: normal glycemic control (healthy; n = 21), reversed prediabetes
(prediabetes/healthy; n = 8), prediabetes (n = 8), or type 2 diabetes (n = 10).
A total of 46 taxa were found to be possibly related to progression from healthy
state to type 2 diabetes. Bacteroides coprophilus DSM 18228, Bifidobacterium
pseudocatenulatum DSM 20438, and Bifidobacterium adolescentis ATCC 15703 could
confer resistance to glucose intolerance. On the other hand, Odoribacter laneus
YIT 12061 may be pathogenic as it was found to be more abundant in type 2
diabetes participants than other cohorts. This research increases our
understanding of the structural modulation of gut microbiota in the pathogenesis
of type 2 diabetes and highlights gut microbiota strains, with the potential for
targeted opportunistic pathogen control or consideration for probiotic
prophylaxis and treatment.