Summary

Data Summary

Investigator Leiter, Ed Description The AMDCC performs baseline phenotyping on all the mouse strains developed by the consortium. This experiment contains the data for these measurements. The phenotyping is done over a 25 week time frame were samples are taken at 4, 8, 12, 16, 20, 24 and 25 weeks of age. Status In Progress Public Release 7/1/2009 Data Collected? Data will not be collected for this catalog item Species M. musculus Animal Age Measured In: week(s) post-natal (w) Data Analysis  Browse Data DOWNLOAD ALL DATA (.csv) PhenStat Result(s)  ANOVA Statistics  Basic Statistics  Chart Exploration

Type Count Released Animals 770 - Experimental Conditions 1 - Phenotype Assays 48 - Phenotype Measurements 40903 40903 Microarrays 0 - Histology Images 135 135 Publications 0 -

Animals
Strain Name Common Name Females Males Unknown C57BL/6J C57BL/6J 16 18 0 B6.129S7-Ldlrtm1Her/J C57BL/6J-Ldlr-/- 0 16 0 B6.129P2-Nos3tm1Unc C57BL/6J-eNOS-/- 7 6 0 B6.129P2-Apoetm1Unc/J Apoe-/- 7 8 0 129S6/SvEvTac 129S6/SvEvTac 8 7 0 DBA/2J DBA/2J 8 23 0 FVB/NJ FVB/NJ 13 9 0 C57BL/6J-Ins2Akita C57BL/6J Akita 20 16 0 FVB.BKS(D)-Lepr db/ChuaJ FVB db/db 10 12 0 FVB.BKS(D)-+/?/ChuaJ FVB.BKS(D)-+/?/ChuaJ 6 6 0 C57BL/6-Ins2Akita Bdkrb1/Bdkrb2tm2Mki/J B6.Bdkrb1/2 KO, Akita 8 10 0 D2.Cg-Nr1h4tm1Gonz/J DBA/2-FXR-/- 8 7 0 FVB.Cg-Nr1h4tm1Gonz/J FVB.FXR-/- 8 6 0 FVB.Cg-Ins2Akita Nr1h4tm1Gonz/J FVB.FXR-/- Akita 8 8 0 D2.Cg-Ins2 Akita Nr1h4tm1Gonz/J DBA2.FXR-/- Akita 9 10 0 D2.B6-Ins2Akita/MatbJ DBA2-Akita 14 27 0 FVB.B6-Ins2Akita/MlnJ FVB-Akita 15 13 0 C57BL/6-Bdkrb1/Bdkrb2tm2Mki/J B6.Bdkrb1/2 KO 8 8 0 129B6F1.Cg-Ins2Akita Nos3tm1Unc/J 129B6F1.Cg-Ins2Akita Nos3tm1Unc/J 7 22 0 129B6F1.Cg-Nos3tm1Unc/J 129B6F1.Cg-Nos3tm1Unc/J 8 23 0 129S6.B6-Ins2Akita/CofJ 129S6.B6-Ins2Akita/CofJ 8 9 0 B6.Cg-Ins2Akita Ldlrtm1Her/J B6.Cg-Ins2Akita Ldlrtm1Her/J 0 17 0 FVB(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ FVB.Ove26 13 14 0 BTBR.V(B6)-Lepob/WiscJ BTBR.V(B6)ob/ob 19 20 0 BTBR.V(B6)+/?/WiscJ BTBR.V(B6)+/? 20 21 0 FVB(Cg)+/+/PneJ FVB.Ove26+/+ 8 12 0 (NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ (NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ 9 7 0 (NONFVB)F1+/+ (NONFVB)F1+/+ 8 8 0 (PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) (PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) 9 10 0 (PWKFVB)F1+/+ (PWKFVB)F1+/+ 6 4 0 (ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) (ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) 8 7 0 (ALRFVB)F1+/+ (ALRFVB)F1+/+ 6 6 0 129S6.Cg-Nos3tm1Unc Ins2Akita/J 129S6.Cg-Nos3tm1Unc Ins2Akita/J 12 8 0 129S6.Cg-Nos3tm1Unc Ins2+/+/J 129S6.Cg-Nos3tm1Unc Ins2+/+/J 6 8 0 C57BL/6-Ins2AkitaApoetm1Unc/J C57BL/6-Ins2AkitaApoe-/-/J 8 9 0 C57BL/6-Ins2AkitaNos3tm1Unc/J C57BL/6-Ins2AkitaNos3-/-/J 7 9 0 B6.129-Apoetm3(APOE*4)Mae Ins2Akita Ldlrtm1(LDLR)Mae/J B6.129-Apoetm3(APOE*4)Mae Ins2Akita Ldlrtm1(LDLR)Mae/J 2 5 0 B6.129-Apoetm3(APOE*4)Mae Ldlrtm1(LDLR)Mae/J B6.129-Apoetm3(APOE*4)Mae Ldlrtm1(LDLR)Mae/J 2 2 0

Experimental Conditions
Name Units Mouse Diet one of [3mAIN76(HF0.18), 3mAIN76(HF0.18)early, ...]

Histology Images Caption Strain Anatomical Site cervical fat in normoglycemic FVB-+/? male control [Consortial] FVB.BKS(D)-+/?/ChuaJ adipose tissue Liver from 26 wk old FVB-+/? male [Consortial] FVB.BKS(D)-+/?/ChuaJ liver pancreas from normoglycemic FVB-+/? male control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas Aperio slide scan of pancreas from chronically hyperglycemic 26-wk-old FVB-Lepr male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Marked beta cell degranulation in a hyperplastic hypertrophied pancreatic islet from a chronically hyperglycemic 26-wk-old FVB-Lepr male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Marked beta cell degranulation in a hyperplastic hypertrophied pancreatic islet from a chronically hyperglycemic 26-wk-old FVB-Lepr male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aldehyde fuchsin positive cells in proliferating pancreatic ductal structures (neogenesis?) [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aperio slide scan of pancreas from FVB.BKS(D)-+/?/ChuaJ male control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ Male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aperio slide scan of pancreas from FVB.BKS(D)-+/?/ChuaJ male control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas pancreas in normoglycemic FVB-+/? female control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas Aperio slide scan of pancreas from 26-wk-old FVB-Lepr female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aperio slide scan of pancreas from normal FVB.BKS(D)-Lepr /ChuaJ Male control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas Normal well-granulated islet in FVB-+/? male [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas cervical fat in hyperglycemic FVB-db/db male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ adipose tissue Marked hepatosteatosis in 26 wk old FVB-db/db male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ liver Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas pancreas from female FVB.BKS(D)-Lepr experimental animal [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr db/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas pancreas from 26-wk-old FVB-Leprdb/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Leprdb/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aperio slide scan of pancreas from normoglycemic FVB-+/? female control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas pancreas from normoglycemic FVB-+/? female control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ male [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas FVB-+/Akita female [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas Aperio slide scan of pancreas from normoglycemic FVB-+/? female control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas pancreas from normoglycemic FVB-+/? female control [Consortial] FVB.BKS(D)-+/?/ChuaJ pancreas Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr db/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aperio Slide scan of pancreas from 26-wk-old FVB-Lepr db/db [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr db/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Aperio Slide scan of pancreas from 26-wk-old FVB-Lepr [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ pancreas Normal appearing kidney 26-wk-old FVB-db/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ kidney Normal appearing kidney 26-wk-old FVB-db/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ kidney Normal appearing kidney 26-wk-old -db/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ kidney Normal appearing kidney 26-wk-old FVB-db/db female [Consortial] FVB.BKS(D)-Lepr db/ChuaJ kidney Normal appearing kidney in 26-wk-old FVB-+/? female [Consortial] FVB.BKS(D)-+/?/ChuaJ kidney Normal appearing kidney in 26-wk-old FVB-+/? female [Consortial] FVB.BKS(D)-+/?/ChuaJ kidney Normal glomeruli in non-diabetic FVB-+/+ female [Consortial] FVB/NJ kidney cortex Normal islet in FVB-+/+ female [Consortial] FVB/NJ pancreas normal islet in FVB-+/+ female control [Consortial] FVB/NJ pancreas normal islet in FVB-+/+ female control [Consortial] FVB/NJ pancreas normal islet in FVB-+/+ female control [Consortial] FVB/NJ pancreas silver methenamine stain Female FVB Akita control [Consortial] FVB/NJ kidney cortex Normal appearing renal cortex of FVB-Akita female, silver methenamine stain [Consortial] FVB.B6-Ins2Akita/MlnJ kidney cortex FVB-Akita female, normal appearing renal cortex of silver methenamine stain [Consortial] FVB.B6-Ins2Akita/MlnJ kidney cortex FVB-+/Akita female [Consortial] FVB.B6-Ins2Akita/MlnJ pancreas FVB-+/Akita female [Consortial] FVB.B6-Ins2Akita/MlnJ pancreas Partially insulin-degranulated islets in FVB-Akita diabetic female [Consortial] FVB.B6-Ins2Akita/MlnJ pancreatic islet FVB-Akita female with normal appearing glomeruli, silver methenamine stain [Consortial] FVB.B6-Ins2Akita/MlnJ kidney cortex FVB-+/Akita female [Consortial] FVB.B6-Ins2Akita/MlnJ pancreas FVB-+/Akita male [Consortial] FVB.B6-Ins2Akita/MlnJ pancreas Partially insulin-degranulated islet in FVB-Akita diabetic female [Consortial] FVB.B6-Ins2Akita/MlnJ pancreatic islet normal appearing islets in FVB-+/+ control male [Consortial] FVB/NJ pancreas normal appearing islet in FVB-+/+ control male [Consortial] FVB/NJ pancreas FVB-+/+ male control pancreas [Consortial] FVB/NJ pancreas FVB male wildtype control pancreas [Consortial] FVB/NJ pancreatic islet Normal appearing glomeruli, silver methenamine stain in FVB-+/+ male control [Consortial] FVB/NJ kidney cortex Normal appearing glomeruli in male FVB Akita male, silver methenamine stain [Consortial] FVB.B6-Ins2Akita/MlnJ kidney cortex FVB-+/Akita male [Consortial] FVB.B6-Ins2Akita/MlnJ pancreas FVB-+/Akita male [Consortial] FVB.B6-Ins2Akita/MlnJ pancreas FVB-+/Akita male [Consortial] FVB.B6-Ins2Akita/MlnJ pancreas silver methenamine [Consortial] 129B6F1.Cg-Ins2Akita Nos3tm1Unc/J kidney silver methenamine [Consortial] 129B6F1.Cg-Ins2Akita Nos3tm1Unc/J kidney Silver methenamine stained kidney [Consortial] 129B6F1.Cg-Ins2Akita Nos3tm1Unc/J kidney cortex Normal glomeruli [Consortial] 129B6F1.Cg-Nos3tm1Unc/J kidney cortex Glomerulus with ischemic changes [Consortial] 129B6F1.Cg-Nos3tm1Unc/J kidney cortex Glomerular lesion [Consortial] 129B6F1.Cg-Nos3tm1Unc/J kidney cortex Kidney cortex - one glomerulus with lesion [Consortial] 129B6F1.Cg-Nos3tm1Unc/J kidney Kidney [Consortial] FVB.Cg-Ins2Akita Nr1h4tm1Gonz/J kidney FVB-FXRnull non-diabetic female control liver showing severe macrovesicular hepatosteatosis [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic female control liver showing severe macrovesicular hepatosteatosis [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver Kidney cortex [Consortial] FVB.Cg-Nr1h4tm1Gonz/J kidney Glomeruli with expanded mesangial matrix [Consortial] FVB.Cg-Nr1h4tm1Gonz/J kidney cortex Interstitial inflammation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J kidney cortex Kidney with patchy interstitial fibrosis [Consortial] FVB.Cg-Nr1h4tm1Gonz/J kidney FVB-FXRnull non-diabetic male control liver with ceroid-like pigment in bile canaliculi [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic male control liver with ceroid-like pigment in bile canniculi [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic control liver showing widespread ceroid-like pigment [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic control liver showing hepatosteatosis [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic male control liver showing macrovesicular steatosis [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic control liver showing focal macrovesicular hepatosteatosis [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver FVB-FXRnull non-diabetic control liver showing ceroid-like pigment accumulation [Consortial] FVB.Cg-Nr1h4tm1Gonz/J liver One glomerulus with expanded mesangial matrix and mesangiolysis, others are normal [Consortial] D2.Cg-Ins2 Akita Nr1h4tm1Gonz/J kidney cortex Some glomeruli have expanded mesangial matrix and mesangiolysis [Consortial] D2.Cg-Ins2 Akita Nr1h4tm1Gonz/J kidney cortex Kidney cortex with focal interstitial fibrosis [Consortial] D2.Cg-Ins2 Akita Nr1h4tm1Gonz/J kidney cortex Glomeruli with expanded mesangial matrix [Consortial] D2.Cg-Ins2 Akita Nr1h4tm1Gonz/J kidney cortex Silver methenamine stained [Consortial] BTBR.V(B6)+/?/WiscJ kidney Silver methenamine stained [Consortial] BTBR.V(B6)-Lepob/WiscJ kidney Silver methenamine stained [Consortial] BTBR.V(B6)-Lepob/WiscJ kidney Kidney lesions - increased mesangial matrix [Consortial] BTBR.V(B6)-Lepob/WiscJ kidney Silver methenamine stained [Consortial] BTBR.V(B6)-Lepob/WiscJ kidney Silver methenamine stained [Consortial] BTBR.V(B6)-Lepob/WiscJ kidney Kidney cortex [Consortial] (ALRFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (ALRFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (ALRFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (ALRFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (ALRFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (PWKFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (PWKFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (PWKFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ) kidney cortex Kidney cortex [Consortial] (NONFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (NONFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ kidney cortex Kidney cortex [Consortial] (NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ kidney cortex Kidney cortex [Consortial] (NONFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (NONFVB)F1+/+ kidney cortex Kidney cortex [Consortial] (NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ kidney cortex Silver methenamine stained [Consortial] D2.B6-Ins2Akita/MatbJ kidney Whole slide scan - Silver methenamine stain [Consortial] D2.B6-Ins2Akita/MatbJ kidney Heart mineralization in severely diabetic DBA/2-Akita male [Consortial] D2.B6-Ins2Akita/MatbJ heart Epicardial mineralization in severely diabetic DBA/2-Akita male [Consortial] D2.B6-Ins2Akita/MatbJ heart Kidney lesions in 6 month-old Akita male [Consortial] D2.B6-Ins2Akita/MatbJ kidney Kidney of 6 month Akita male [Consortial] D2.B6-Ins2Akita/MatbJ kidney Atrophic islets in pancreas of severely diabetic DBA/2-Akita male [Consortial] D2.B6-Ins2Akita/MatbJ pancreatic islet Pancreatic islet in severely diabetic DBA/2 Akita male [Consortial] D2.B6-Ins2Akita/MatbJ pancreatic islet Kidney from 26 wk old DBA/2-Akita male [Consortial] D2.B6-Ins2Akita/MatbJ kidney Silver methenamine stained kidney [Consortial] DBA/2J kidney cortex

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