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DiaComp Funded Abstracts

Program Application Abstract

A review of biopsies in patients with diabetes mellitus.
Roark, Travis   (University of Washington)
Diabetes is currently the leading cause of end stage renal disease in the US. Diabetic nephropathy (DN) is a common manifestation of end organ damage due to diabetes. However, it is important to confirm a causative diagnosis if there are signs or symptoms inconsistent with the typical progression of DN. A diagnosis other than DN may change the treatment regiment, leading to better patient outcomes. Part of the diagnostic workup can include a kidney biopsy. Constructing a data set from both pathology reports and clinical records provides valuable information to analyze in this patient population. Clinical information and lab values can be cross correlated with pathology diagnosis and histological findings. This data can be used to identify the diagnostic composition of DN vs other causes of kidney disease. It is also easy to determine the spectrum and prevalence of pathology diagnoses in people with diabetes who receive a kidney biopsy. The patients in this study were greater than 18 years old at the time of biopsy. All the biopsies are from a native kidney (transplants were excluded). The time frame includes biopsies ranging from 2010-­2016. This study includes patient from within the University of Washington Health system as well as referred patients. The data was acquired using an Amalga data extraction in combination with manual chart review. The data was consolidated into either excel or RedCap and can be cross referenced using accession numbers. Data tabulation was done with R3.3.1. The diagnostic compositions in this study are consistent with those reported in the literature. Preliminary analysis suggests there are important clinical and laboratory indicators that can serve to help differentiate between DN and other types of kidney disease.