DiaComp Funded Abstracts
Program Application Abstract
Aortic volume analysis may give insight into many disease states and reveal information on potential cardiovascular (CV) risk factors
(Johns Hopkins University)
Summer Student Program
Aortic volume analysis may give insight into many disease states and reveal information on potential cardiovascular (CV) risk factors. Cardiac magnetic resonance imaging (CMR) was used to measure thoracic aortic volumes at three levels: aortic arch, ascending, and descending aorta. The association of thoracic aortic volume with age, gender, and traditional CV risk factors has not been explored. The aim of the study is to research the association of these factors on thoracic aortic volume using 1,172 Multi-Ethnic Study of Atherosclerosis (MESA) participants (ages 45-84 years) who underwent CMR at exam 5. Multiple regression models were generated using STATA to determine the relationship between risk factors and thoracic aortic volume. The average total thoracic aortic volume is 138.64+40.82mL. The total volumes ranged from 55.16 to 325. 27mL. Thoracic aortic volume increases with both height and weight, although it is more strongly correlated to height. The thoracic aortic volume was correlated to male gender, age, and race before and after indexing for height^1.7. In addition, the thoracic aortic volume is statistically significant with body mass index, diastolic blood pressure, use of hypertension medications, and treated diabetes as indicated by p-values <0.05. Patients with treated diabetes had significantly lower thoracic aortic volume. However, patients with impaired fasting glucose and untreated diabetes had no change in their aortic volume relative to non-diabetic patients. Left ventricular (LV) ejection fraction, LV mass, LV end-diastolic volume, ascending and descending aortic distensibility, and aortic arch pulse wave velocity were found to be statistically significant before and after adjusting for the above significant CV risk factors. These data suggest that thoracic aortic volume can be utilized as an important marker in characterizing aortic complications and monitoring of CV events and heart failure.
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