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Metabolic Phenotype Data Search

DBA/2J

DBA/2J is a widely used inbred strain that is valuable in a large number of research areas, including cardiovascular biology, neurobiology, and sensorineural research. Its characteristics are often contrasted with those of the C57BL/6J inbred strain (Stock No. 000664). DBA/2J mice show a low susceptibility to developing atherosclerotic aortic lesions (20 to 350 um2 atherosclerotic aortic lesions /aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). They also exhibit high-frequency hearing loss beginning roughly at the time of weaning/adolescence (between three to four weeks of age) and becoming severe by two to three months of age. The age related hearing loss 8 mutation arose spontaneously in DBA/2J between 1951 and 1975. This strain possesses three recessive alleles that cause progressive cochlear pathology initially affecting the organ of Corti. Decreasing anteroventral cochlear nucleus volume decreases and neuron loss parallel the progression of peripheral hearing loss. Young DBA/2J inbred mice are also susceptible to audiogenic seizures due to the asp2 mutation, however, this susceptibility decreases as animals reach adulthood. There is high incidence of calcareous pericarditis, and calcified lesions of the testes, tongue and skeletal muscle. This strain is among the least responsive to phytohemagglutinin (Heiniger et al., 1975).


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
DBA/2JBoth125179.8751.27
 Female38171.3722.75
 Male87183.5959.21
Avg = 199.6
Std = 53.58
N = 10
Age = 26 Avg = 182.33
Std = 43.72
N = 24
Age = 24 Avg = 180.7
Std = 33.82
N = 10
Age = 20 Avg = 183.75
Std = 17.66
N = 12
Age = 16 Avg = 166.92
Std = 26.44
N = 26
Age = 12 Avg = 170.96
Std = 15.81
N = 26
Age = 8 Avg = 235.8
Std = 190.92
N = 5
Age = 5 Avg = 178
Std = 21.54
N = 12
Age = 4 Avg = 199.6
Std = 53.58
N = 10
Age = 26 Avg = 182.33
Std = 43.72
N = 24
Age = 24 Avg = 180.7
Std = 33.82
N = 10
Age = 20 Avg = 183.75
Std = 17.66
N = 12
Age = 16 Avg = 166.92
Std = 26.44
N = 26
Age = 12 Avg = 170.96
Std = 15.81
N = 26
Age = 8 Avg = 235.8
Std = 190.92
N = 5
Age = 5 Avg = 178
Std = 21.54
N = 12
Age = 4

insulin, plasma (pg/ml)

SeriesSexNAvgSD
DBA/2JBoth805133.485998.75
 Female182320.391906.58
 Male625950.186512.48
Avg = 8763.71
Std = 9415.53
N = 24
Age = 24 Avg = 3430.25
Std = 2279.45
N = 12
Age = 16 Avg = 5694.07
Std = 2552.31
N = 14
Age = 12 Avg = 2913.84
Std = 1354.76
N = 25
Age = 8 Avg = 1324.6
Std = 316.16
N = 5
Age = 5 Avg = 8763.71
Std = 9415.53
N = 24
Age = 24 Avg = 3430.25
Std = 2279.45
N = 12
Age = 16 Avg = 5694.07
Std = 2552.31
N = 14
Age = 12 Avg = 2913.84
Std = 1354.76
N = 25
Age = 8 Avg = 1324.6
Std = 316.16
N = 5
Age = 5

W rodent (g)

SeriesSexNAvgSD
DBA/2JBoth20430.256.40
 Male18830.926.16
 Female1622.382.98
Avg = 37.45
Std = 4.16
N = 14
Age = 26 Avg = 34.34
Std = 5.41
N = 19
Age = 24 Avg = 30.72
Std = 6.62
N = 33
Age = 22 Avg = 34.72
Std = 4.7
N = 18
Age = 20 Avg = 31.59
Std = 4.94
N = 20
Age = 18 Avg = 33.46
Std = 2.76
N = 14
Age = 16 Avg = 31.53
Std = 3.33
N = 15
Age = 14 Avg = 29.14
Std = 3.66
N = 16
Age = 12 Avg = 27.11
Std = 3.56
N = 16
Age = 10 Avg = 25.11
Std = 2.33
N = 18
Age = 8 Avg = 22.02
Std = 1.97
N = 15
Age = 6 Avg = 17.3
Std = 1.85
N = 5
Age = 5 Avg = 14.6
Std = 0
N = 1
Age = 4 Avg = 37.45
Std = 4.16
N = 14
Age = 26 Avg = 34.34
Std = 5.41
N = 19
Age = 24 Avg = 30.72
Std = 6.62
N = 33
Age = 22 Avg = 34.72
Std = 4.7
N = 18
Age = 20 Avg = 31.59
Std = 4.94
N = 20
Age = 18 Avg = 33.46
Std = 2.76
N = 14
Age = 16 Avg = 31.53
Std = 3.33
N = 15
Age = 14 Avg = 29.14
Std = 3.66
N = 16
Age = 12 Avg = 27.11
Std = 3.56
N = 16
Age = 10 Avg = 25.11
Std = 2.33
N = 18
Age = 8 Avg = 22.02
Std = 1.97
N = 15
Age = 6 Avg = 17.3
Std = 1.85
N = 5
Age = 5 Avg = 14.6
Std = 0
N = 1
Age = 4

fat body mass (g)

SeriesSexNAvgSD
DBA/2JBoth107.913.94
 Female45.050.63
 Male69.824.07
Avg = 7.91
Std = 3.94
N = 10

lean body mass (g)

SeriesSexNAvgSD
DBA/2JBoth1020.853.44
 Female417.850.39
 Male622.853.11
Avg = 20.85
Std = 3.44
N = 10

%BF (rodent) (%)

SeriesSexNAvgSD
DBA/2JBoth1026.076.46
 Female421.952.05
 Male628.826.91
Avg = 26.07
Std = 6.46
N = 10