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Publication
The ratio of pericardial to subcutaneous adipose tissues is associated with
insulin resistance.
Authors Alman AC, Smith SR, Eckel RH, Hokanson JE, Burkhardt BR, Sudini PR, Wu Y,
Schauer IE, Pereira RI, Snell-Bergeon JK
Submitted By Submitted Externally on 7/25/2017
Status Published
Journal Obesity (Silver Spring, Md.)
Year 2017
Date Published 7/1/2017
Volume : Pages 25 : 1284 - 1291
PubMed Reference 28558132
Abstract To examine the association between pericardial adipose tissue (PAT) and the
ratio of PAT to subcutaneous adipose tissue (SAT) with insulin resistance in
adults with and without type 1 diabetes (T1D)., Data for this report came from a
substudy of the Coronary Artery Calcification in Type 1 Diabetes cohort (n?=?83;
38 with T1D, 45 without T1D). Insulin resistance was measured by
hyperinsulinemic-euglycemic clamp. Abdominal computed tomography (CT) was used
to measure visceral adipose tissue (VAT) and SAT. PAT was measured from CT scans
of the heart., PAT and the ratio of PAT to SAT was higher in males compared to
females. After adjustment for demographics, diabetes, blood pressure and lipid
factors, BMI, VAT, and log PAT/SAT ratio, log PAT was positively associated with
the glucose infusion rate (GIR) in females only (ß?=?3.36?±?1.96, P?=?0.097, P
for sex interaction?=?0.055). Conversely, the log PAT/SAT ratio was
significantly associated with decreased GIR in both males and females
(ß?=?-2.08?±?1.03, P?=?0.047, P for sex interaction?=?0.768)., A significant
association between the PAT/SAT ratio and insulin resistance was found,
independent of BMI, VAT, and PAT. These results highlight the importance of
considering fat distribution independent of volume.

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