E. Dale Abel

Personal Information
Title Professor
Expertise Cardiomyopathy
Institution University of Iowa
Data Summary
TypeCount
Grants/SubContracts 1
Progress Reports 5
Presentations 5
Publications 74
Protocols 9
Committees 1
Experiments 0
Strains 4
Models 3

Modeling Diabetic Cardiomyopathy and Microangiopathy
Grant Number: HL087947

Abstract: This proposal is submitted to become a pathobiology site in the renewal of the Animal Models of Diabetic Complications Consortium (AMDCC). The University of Utah site proposes to generate two mouse models. The first will address mechanisms that are responsible for diabetic cardiomyopathy, and the second will model the role of impaired angiogenesis and arteriogenesis in the pathogenesis of ischemic complications of diabetes. Our studies in the first phase of the consortium revealed that diabetic cardiomyopathy (particularly in type 2 diabetes) was characterized by impaired myocardial insulin action, mitochondria! dysfunction, oxidative stress, increased FA utilization, decreased glucose utilization and lipotoxicity. Mice with cardiomyocyte-restricted deletion of insulin receptors (CIRKO), developed many of the features of diabetic cardiomyopathy but did not have a persistent increase in FA oxidation, did not develop lipotoxicity and had modest defects in cardiac function. We therefore propose to introduce into CIRKO mice an Acyl-CoA synthetase transgene that will modestly increased myocardial FA delivery in a sensitized background of mitochondrial superoxide (Sod2) haploinsufficency. We will then determine if these mice meet established AMDCC criteria for diabetic cardiomyopathy, determine if they exhibit characteristic defects in mitochondrial function and substrate utilization and test the hypothesis that they will be more susceptible to dysfunction in the face of LV hypertrophy.This model represents a powerful platform with which to test the direct effect of various therapeutic strategies on diabetic cardiomyopathy, independently of effects on systemic metabolism. We will also generate a mouse in the type -1 diabetes (Akita) background with temporal and cell-type restricted expression of a novel angiogenic factor netrin 1. We will use this mouse to determine if the maintenance of arteriogenesis and angiogenesis, by activating this transgene in the heart or the hind-limb will be sufficient to ameliorate the accelerated LV remodeling that characterizes diabetic hearts following coronary artery ligation, or reverse impaired recovery of hind-limb perfusion that occurs in diabetic animals following femoral artery occlusion. This model will also be a powerful platform with which to evaluate the role of impaired angiogenesis (in the pathogenesis), or therapeutic angiogenesis (in the treatment) of other ischemic complications of diabetes such as impaired wound healing, neuropathy or nephropathy.


Institution: University of Iowa
101 Jessup Hall
Iowa City, IA
Fiscal Year:2006
Department:INTERNAL MEDICINE
Project Start: 9/4/2006
Project End: 8/31/2011
ICD: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Progress Reports

No funding program application progress reports found.

Annual Reports

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Abel, Dale (2007)
2007Annual Report
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Abel, Dale (2008)
2008Annual Report
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Abel, Dale (2009)
2009Annual Report
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Abel, Dale (2010)
2010Annual Report
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Abel, Dale (2011)
2011Annual Report
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 PublicationAltmetricsSubmitted ByPubMed IDStatus

Year: 2016; Items: 1

 
Insulin Signaling and Heart Failure.
Riehle C, Abel ED
Circulation research, 2016 (118), 1151 - 69
27034277
Published

Year: 2015; Items: 1

 
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration.
Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV
Nature neuroscience, 2015 (18), 521 - 530
Submitted Externally
25730668
Published

Year: 2014; Items: 9

 
Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.
Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A
Diabetes, 2014 (63), 701 - 714
24101677
Published
 
The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.
Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M
American journal of physiology. Heart and circulatory physiology, 2014 (306), H747 - H754
Submitted Externally
24375641
Published
 
Molecular mechanisms of diabetic cardiomyopathy.
Bugger H, Abel ED
Diabetologia, 2014 (57), 660 - 671
24477973
Published
 
GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure.
Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Riehle C, Abel ED
Journal of molecular and cellular cardiology, 2014 (72C), 95 - 103
24583251
Published
 
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.
Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC
Journal of immunology (Baltimore, Md. : 1950), 2014 (192), 3626 - 36
Submitted Externally
24616478
Published
 
Maintaining PGC-1a expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.
Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014 (28), 3691 - 702
24776744
Published
 
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.
Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC
Cell Metabolism, 2014 (20), 61 - 72
Submitted Externally
24930970
Published
 
Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.
Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED
Molecular and cellular biology, 2014 (34), 3450 - 60
25002528
Published
 
Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC
Cell death & disease, 2014 (5), e1470
Submitted Externally
25321477
Published

Year: 2013; Items: 7

 
Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes.
Marcus RL, Addison O, LaStayo PC, Hungerford R, Wende AR, Hoffman JM, Abel ED, McClain DA
Journal of endocrinological investigation, 2013 (36), 111 - 117
Submitted Externally
22522495
Published
 
Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia.
Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB
Experimental physiology, 2013 (98), 746 - 757
Submitted Externally
23180812
Published
 
Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide.
Symons JD, Abel ED
Reviews in endocrine & metabolic disorders, 2013 (14), 59 - 68
23292334
Published
 
Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.
Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED
PLoS ONE, 2013 (8), e54221
23342106
Published
 
Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms.
Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S
Journal of molecular and cellular cardiology, 2013 (64), 20 - 29
Submitted Externally
23994159
Published
 
Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction.
Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Anderson SM, Abel ED
Journal of the American Heart Association, 2013 (2), e000301
24052497
Published
 
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED
The Journal of clinical investigation, 2013 (123), 5319 - 5333
24177427
Published

Year: 2012; Items: 8

 
Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.
Li Y, Wende AR, Nunthakungwan O, Huang Y, Hu E, Jin H, Boudina S, Abel ED, Jalili T
The FEBS journal, 2012 (279), 599 - 611
Submitted Externally
22221582
Published
 
Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.
Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED
Journal of molecular and cellular cardiology, 2012 (52), 1019 - 1026
22342406
Published
 
Modulation of the cardiovascular system by leptin.
Abel ED, Sweeney G
Biochimie, 2012 (94), 2097 - 2103
22490727
Published
 
Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.
Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED
Endocrinology, 2012 (153), 2677 - 2688
22510273
Published
 
Insulin resistance: metabolic mechanisms and consequences in the heart.
Abel ED, O'Shea KM, Ramasamy R
Arteriosclerosis, thrombosis, and vascular biology, 2012 (32), 2068 - 2076
22895668
Published
 
UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice.
Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, Olsen C, Sena S, Abel ED
Diabetes, 2012 (61), 3260 - 3269
22912419
Published
 
PGC-1 proteins and heart failure.
Riehle C, Abel ED
Trends in cardiovascular medicine, 2012 (22), 98 - 105
22939990
Published
 
Mechanisms of lipotoxicity in the cardiovascular system.
Wende AR, Symons JD, Abel ED
Current hypertension reports, 2012 (14), 517 - 531
23054891
Published

Year: 2011; Items: 6

 
20876715
Published
 
Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload.
Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CL, Sena S, Abel ED, Litwin SE
American journal of physiology. Heart and circulatory physiology, 2011 (300), H374 - H381
20971769
Published
 
Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy.
Abel ED, Doenst T
Cardiovascular research, 2011 (90), 234 - 242
21257612
Published
 
Obesity stresses cardiac mitochondria even when you are young.
Abel ED
Journal of the American College of Cardiology, 2011 (57), 586 - 589
21272750
Published
 
Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted ob/ob Mice.
Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel ED
Diabetes, 2011 (60), 1424 - 1434
21441440
Published
 
Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis.
Poussin C, Ibberson M, Hall D, Ding J, Soto J, Abel ED, Thorens B
Diabetes, 2011 (60), 2216 - 2224
Submitted Externally
21752958
Published

Year: 2010; Items: 9

 
Lipotoxicity in the heart.
Wende AR, Abel ED
Biochimica et biophysica acta, 2010 (1801), 311 - 319
19818871
Published
 
Diabetic cardiomyopathy, causes and effects.
Boudina S, Abel ED
Reviews in endocrine & metabolic disorders, 2010 (11), 31 - 39
20180026
Published
 
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I
The Journal of clinical investigation, 2010 (120), 1506 - 1514
20407209
Published
 
Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.
Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED
Endocrinology, 2010 (151), 3536 - 3542
20501666
Published
 
Mitochondria in the diabetic heart.
Bugger H, Abel ED
Cardiovascular research, 2010 (88), 229 - 240
20639213
Published
 
Aberrant water homeostasis detected by stable isotope analysis.
O'Grady SP, Wende AR, Remien CH, Valenzuela LO, Enright LE, Chesson LA, Abel ED, Cerling TE, Ehleringer JR
PLoS ONE, 2010 (5), e11699
Submitted Externally
20657736
Published
 
An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart.
Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel ED, Sweeney G
American journal of physiology. Endocrinology and metabolism, 2010 (299), E721 - E729
Submitted Externally
20739511
Published
 
PPARg-induced cardiolipotoxicity in mice is ameliorated by PPARa deficiency despite increases in fatty acid oxidation.
Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ
The Journal of clinical investigation, 2010 (120), 3443 - 3454
20852389
Published
 
Free fatty acid oxidation in insulin resistance and obesity.
Abel ED
Heart and metabolism : management of the coronary patient, 2010 (48), 5 - 10
23646039
Published

Year: 2009; Items: 6

 
Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding.
Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED
Cardiovascular research, 2009 (82), 351 - 360
19147655
Published
 
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.
Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED
Circulation, 2009 (119(9)), 1272 - 1283
19237663
Published
 
Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.
Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE.
Journal of molecular and cellular cardiology, 2009 (46(6)), 910 - 918
19249310
Published
 
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED
Circulation research, 2009 (104), 1085 - 1094
19342603
Published
 
Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.
Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED
Diabetes, 2009 (58(9)), 1986 - 1997
19542201
Published
 
Rodent models of diabetic cardiomyopathy.
Bugger H, Abel ED
Disease models & mechanisms, 2009 (2), 454 - 466
19726805
Published

Year: 2008; Items: 5

 
18184113
Published
 
Cardiac Remodeling in Obesity
Abel ED, Litwin SE, Sweeney G
Physiological reviews, 2008 (88), 389 - 419
18391168
Published
 
Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts
Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED.
Endocrinology, 2008 (149), 4043 - 4050
18450963
Published
 
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.
Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ
Journal of lipid research, 2008 (49), 2101 - 2112
18515784
Published
 
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3
Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED
Diabetes, 2008 (57), 2924 - 2932
18678617
Published

Year: 2007; Items: 6

 
Recipes for Creating Animal Models of Diabetic Cardiovascular Disease
Willa Hsueh, E. Dale Abel, Jan L. Breslow, Nobuyo Maeda, Richard C. Davis, Edward A. Fisher, Hayes Dansky, Donald A. McClain, Richard McIndoe, Momtaz K. Wassef, Cristina Rabadan-Diehl, Ira J. Goldberg
Circulation research, 2007 (100), 1415 - 1427
17525381
Published
 
Diabetic Cardiomyopathy Revisited
Sihem Boudina and E. Dale Abel
Circulation, 2007 (115), 3213 - 3223
17592090
Published
 
Mitochondrial energetics in the heart in obesity related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins
Sihem Boudina, Sandra Sena, Heather Theobald, Xiaoming Sheng, Jordan J. Wright, Xia Xuan Hu, Salwa Aziz, Josie I. Johnson, Heiko Bugger,Vlad G. Zaha and E. Dale Abel
Diabetes, 2007 (56(10)), 2457 - 2466
17623815
Published
 
Glucose for the aging heart?
Abel ED
Circulation, 2007 (116(8)), 884 - 887
17709649
Published
 
Cardiac Hypertrophy Caused by Peroxisome Proliferator Activated Receptor-Gamma Agonist Treatment Occurs Independently of Changes in Myocardial Insulin Signaling
Sandra Sena, Isaac R. Rasmussen, Adam R. Wende, Alfred P. McQueen, Heather A. Theobald, Nicole Wilde, Renata Oliveira Pereira, Sheldon E. Litwin, Joel P. Berger, E. Dale Abel
Endocrinology, 2007 (148(12)), 6047 - 6053
17823261
Published
 
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.
O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED
Cell Metabolism, 2007 (6), 294 - 306
17908558
Published

Year: 2006; Items: 2

 
Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes
Sihem Boudina and E. Dale Abel
Physiology (Bethesda, Md.), 2006 (21), 250 - 258
16868314
Published
 
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.
Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A
PLoS biology, 2006 (4), e369
Submitted Externally
17090215
Published

Year: 2005; Items: 6

 
Metabolic perturbations in the diabetic heart: Mechanisms and molecular targets
E. Dale Abel
Drug discovery today, 2005 (2), 115 - 122
 
Published
 
Akt1 in the cardiovascular system: friend or foe?
O'Neill BT, Abel ED
The Journal of clinical investigation, 2005 (115), 2059 - 2064
16075047
Published
 
Myocardial Insulin Resistance and Cardiac Complications of Diabetes
E. Dale Abel
Current drug targets. Immune, endocrine and metabolic disorders, 2005 (5), 219 - 226
16089356
Published
 
Reduced Cardiac Efficiency and Altered Substrate Metabolism Precedes the Onset of Hyperglycemia and Contractile Dysfunction in Two Mouse Models of Insulin Resistance and Obesity
Jonathan Buchanan, Pradip K. Mazumder, Ping Hu, Gopa Chakrabarti, Matthew W. Roberts, Ui Jeong Yun, Robert C. Cooksey, Sheldon E. Litwin, and E. Dale Abel
Endocrinology, 2005 (146), 5341 - 5349
16141388
Published
 
Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density
Alfred P. McQueen, Dongfang Zhang, Ping Hu, LeAnne Swenson, Ying Yang, Vlad G. Zaha, James L. Hoffman, Ui Jeong Yun, Gopa Chakrabarti, ZhengmingWang, Kurt H. Albertine, E. Dale Abel, Sheldon E. Litwin
Journal of molecular and cellular cardiology, 2005 (39), 882 - 892
16216265
Published
 
Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impairs Myocardial Energetics in Obesity
Sihem Boudina, Sandra Sena, Brian T O'Neill, Prakash Tathireddy, Martin E Young, and E. Dale Abel
Circulation, 2005 (112), 2686 - 2695
16246967
Published

Year: 2004; Items: 4

 
Glucose transport in the heart.
Abel ED.
Frontiers in bioscience, 2004 (9), 201 - 215
14766360
Published
 
Impaired Cardiac Efficiency and Increased Fatty Acid Oxidation in Insulin-Resistant ob/ob Mouse Hearts.
Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED.
Diabetes, 2004 (53), 2366 - 2374
15331547
Published
 
Insulin Signaling in Heart Muscle: - Lessons from Genetically Engineered
E. Dale Abel
Current hypertension reports, 2004 (6), 416 - 423
15527684
Published
 
Optical Mapping of Propagation Changes Induced by Elevated Extracellular Potassium Ion Concentration in Genetically Altered Mouse Hearts
Bonnie B. Punske, Stefano Rossi, Philip Ershler, Isaac Rasmussen and E. Dale Abel
Journal of electrocardiology, 2004 (37), 128 - 134
15534822
Published

Year: 2003; Items: 2

 
Minimally invasive aortic banding in mice: Effects of altered cardiomyocyte insulin signaling during pressure-overload.
Hu P, Zhang D, Swenson L, Chakrabarti G, Abel ED, Litwin SE.
American journal of physiology. Heart and circulatory physiology, 2003 (285), H1261 - H1269
12738623
Published
 
Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice.
Shimoni Y, Chuang M, Abel ED, Severson DL.
The Journal of physiology, 2003 (555), 345 - 354
14694146
Published

Year: 2002; Items: 1

 
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.
Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel ED.
The Journal of clinical investigation, 2002 (109), 629 - 639
11877471
Published

Year: 2001; Items: 1

 
11413087
Published

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Title YearTypeOptions
Abel, Dale (2009)
2009Presentation
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Abel, E. Dale (10/19/2004)
2004Presentation
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Abel, E. Dale (2005)
2005Presentation
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Abel, E. Dale (2006)
2006Presentation
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Abel, E. Dale (7/2004)
2004Presentation
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No experiments found.