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Experiments Browse Data



Experiment

Baseline Metabolic Phenotyping for DCC Mouse Strains

Summary Data Summary
Investigator Leiter, Ed
Description The AMDCC performs baseline phenotyping on all the mouse strains developed by
the consortium. This experiment contains the data for these measurements. The
phenotyping is done over a 25 week time frame were samples are taken at 4, 8,
12, 16, 20, 24 and 25 weeks of age.
Status In Progress
Public Release 7/1/2009
Data Collected? Data will not be collected for this catalog item
Species M. musculus
Animal Age Measured In: week(s) post-natal (w)
Data Analysis

TypeCountReleased
Animals770-
Experimental Conditions1-
Phenotype Assays48-
Phenotype Measurements4090340903
Microarrays0-
Histology Images135135
Publications0-


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
16
18
0
C57BL/6J-Ldlr-/-
0
16
0
C57BL/6J-eNOS-/-
7
6
0
C57BL/6J-Apoe-/-
7
8
0
129S6/SvEvTac
8
7
0
DBA/2J
8
23
0
FVB/NJ
13
9
0
C57BL/6J Akita
20
16
0
FVB db/db
10
12
0
FVB.BKS(D)-+/?/ChuaJ
6
6
0
B6.Bdkrb1/2 KO, Akita
8
10
0
DBA/2-FXR-/-
8
7
0
FVB.FXR-/-
8
6
0
FVB.FXR-/- Akita
8
8
0
DBA2.FXR-/- Akita
9
10
0
DBA2-Akita
14
27
0
FVB-Akita
15
13
0
B6.Bdkrb1/2 KO
8
8
0
129B6F1.Cg-Ins2Akita Nos3tm1Unc/J
7
22
0
129B6F1.Cg-Nos3tm1Unc/J
8
23
0
129S6.B6-Ins2Akita/CofJ
8
9
0
B6.Cg-Ins2Akita Ldlrtm1Her/J
0
17
0
FVB.Ove26
13
14
0
BTBR.V(B6)ob/ob
19
20
0
BTBR.V(B6)+/?
20
21
0
FVB.Ove26+/+
8
12
0
(NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ
9
7
0
(NONFVB)F1+/+
8
8
0
(PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)
9
10
0
(PWKFVB)F1+/+
6
4
0
(ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)
8
7
0
(ALRFVB)F1+/+
6
6
0
129S6.Cg-Nos3tm1Unc Ins2Akita/J
12
8
0
129S6.Cg-Nos3tm1Unc Ins2+/+/J
6
8
0
C57BL/6-Ins2AkitaApoe-/-/J
8
9
0
C57BL/6-Ins2AkitaNos3-/-/J
7
9
0
B6.129-Apoetm3(APOE*4)Mae Ins2Akita Ldlrtm1(LDLR)Mae/J
2
5
0
B6.129-Apoetm3(APOE*4)Mae Ldlrtm1(LDLR)Mae/J
2
2
0


Experimental Conditions
NameUnits
mouse dietone of [3mAIN76(HF0.18), 3mAIN76(HF0.18)early, ...]


Phenotype Assays Add / Edit

NameAbbreviation
urine albumin (Exocell Albulwell M ELISA)
ualb
creatinine, urine (Exocell Picric Acid method)
ucreat
total cholesterol
TC
cholesterol, HDL (UC)
HDL-UC
blood pressure: systole
sBP
body mass
W rodent
urea nitrogen, blood
BUN
hematocrit
Hct
urine albumin/urine creatinine ratio
ACR
fractional mesangial matrix volume/glomerulus
Vv(MM/glom)
glomerular volume
Glom Vol
total mesangial matrix volume
Tot Mes Matrix Vol
left kidney weight (mouse)
L Kid Wt
right kidney weight (mouse)
R Kid Wt
total albumin excretion
total ualb
insulin, plasma
insulin, plasma
spleen weight
Spleen Wt
spleen:body weight ratio
Spleen:BW
aortic sinus (cross section) lesion area
aortic sinus (cross section) lesion area
heart rate
HR
percent body fat (rodent)
%BF (rodent)
body length A/N (rodent)
A/N (rodent)
urine output
urine output
triglycerides
TG
fat body mass
fat body mass
lean body mass
lean body mass
pulse
pulse
non-esterified free fatty acids
NEFA
glucose, plasma
plasma glucose
leptin
leptin
bone mineral density
BMD
bone mineral content
BMC
bone area
bone area
brain weight (rodent)
brain weight (rodent
glutamine dehydrogenase
GLDH
EKG-Interval between the peak of P-wave to R-wave
EKG-PR
EKG-Interval between R-waves
EKG-RR
EKG-Interval between the peak of P-wave to Q-wave
EKG-PQ
EKG-Interval between the peak of Q-wave to end of T-wave
EKG-QT
EKG-Rate-corrected QT
EKG-QTc
EKG-Beginning to end of QRS complex
EKG-QRS
EKG-Interval between the peak of S-wave to end of T-wave
EKG-ST
Arteriolar Hyalinosis
Arteriolar Hyalinosis
Mesangial Sclerosis
Mesangial Sclerosis
urine albumin (spot)
ualb-spot
creatinine, urine (spot)
ucreatinine-spot
urine albumin/urine creatinine ratio (spot)
ACR-spot
Pancreatic Insulin Content
PIC


Histology Images
CaptionStrainAnatomical Site
cervical fat in normoglycemic FVB-+/? male control [Consortial]FVB.BKS(D)-+/?/ChuaJadipose tissue
Liver from 26 wk old FVB-+/? male [Consortial]FVB.BKS(D)-+/?/ChuaJliver
pancreas from normoglycemic FVB-+/? male control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
Aperio slide scan of pancreas from chronically hyperglycemic 26-wk-old FVB-Lepr male [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Marked beta cell degranulation in a hyperplastic hypertrophied pancreatic islet from a chronically hyperglycemic 26-wk-old FVB-Lepr male [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Marked beta cell degranulation in a hyperplastic hypertrophied pancreatic islet from a chronically hyperglycemic 26-wk-old FVB-Lepr male [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Aldehyde fuchsin positive cells in proliferating pancreatic ductal structures (neogenesis?) [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Aperio slide scan of pancreas from FVB.BKS(D)-+/?/ChuaJ male control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ Male [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Aperio slide scan of pancreas from FVB.BKS(D)-+/?/ChuaJ male control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
pancreas in normoglycemic FVB-+/? female control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
Aperio slide scan of pancreas from 26-wk-old FVB-Lepr female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Aperio slide scan of pancreas from normal FVB.BKS(D)-Lepr /ChuaJ Male control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
Normal well-granulated islet in FVB-+/? male [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
cervical fat in hyperglycemic FVB-db/db male [Consortial]FVB.BKS(D)-Lepr db/ChuaJadipose tissue
Marked hepatosteatosis in 26 wk old FVB-db/db male [Consortial]FVB.BKS(D)-Lepr db/ChuaJliver
Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
pancreas from female FVB.BKS(D)-Lepr experimental animal [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
pancreas from 26-wk-old FVB-Leprdb/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr db/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Leprdb/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Aperio slide scan of pancreas from normoglycemic FVB-+/? female control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
pancreas from normoglycemic FVB-+/? female control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ male [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Aperio slide scan of pancreas from 26 week old FVB.BKS(D)-Lepr /ChuaJ male [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
FVB-+/Akita female [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
Aperio slide scan of pancreas from normoglycemic FVB-+/? female control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
pancreas from normoglycemic FVB-+/? female control [Consortial]FVB.BKS(D)-+/?/ChuaJpancreas
Aperio Slide scan of pancreas from 26-wk-old FVB-Lepr db/db [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr db/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr db/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Aperio Slide scan of pancreas from 26-wk-old FVB-Lepr [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Hyperplastic hypertrophied pancreatic islets from 26-wk-old FVB-Lepr female [Consortial]FVB.BKS(D)-Lepr db/ChuaJpancreas
Normal appearing kidney 26-wk-old FVB-db/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJkidney
Normal appearing kidney 26-wk-old FVB-db/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJkidney
Normal appearing kidney 26-wk-old -db/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJkidney
Normal appearing kidney 26-wk-old FVB-db/db female [Consortial]FVB.BKS(D)-Lepr db/ChuaJkidney
Normal appearing kidney in 26-wk-old FVB-+/? female [Consortial]FVB.BKS(D)-+/?/ChuaJkidney
Normal appearing kidney in 26-wk-old FVB-+/? female [Consortial]FVB.BKS(D)-+/?/ChuaJkidney
Normal glomeruli in non-diabetic FVB-+/+ female [Consortial]FVB/NJkidney cortex
normal islet in FVB-+/+ female control [Consortial]FVB/NJpancreas
Normal islet in FVB-+/+ female [Consortial]FVB/NJpancreas
normal islet in FVB-+/+ female control [Consortial]FVB/NJpancreas
normal islet in FVB-+/+ female control [Consortial]FVB/NJpancreas
silver methenamine stain Female FVB Akita control [Consortial]FVB/NJkidney cortex
FVB-Akita female, normal appearing renal cortex of silver methenamine stain [Consortial]FVB.B6-Ins2Akita/MlnJkidney cortex
Normal appearing renal cortex of FVB-Akita female, silver methenamine stain [Consortial]FVB.B6-Ins2Akita/MlnJkidney cortex
FVB-+/Akita female [Consortial]FVB.B6-Ins2Akita/MlnJpancreas
FVB-+/Akita female [Consortial]FVB.B6-Ins2Akita/MlnJpancreas
Partially insulin-degranulated islets in FVB-Akita diabetic female [Consortial]FVB.B6-Ins2Akita/MlnJpancreatic islet
FVB-Akita female with normal appearing glomeruli, silver methenamine stain [Consortial]FVB.B6-Ins2Akita/MlnJkidney cortex
FVB-+/Akita female [Consortial]FVB.B6-Ins2Akita/MlnJpancreas
FVB-+/Akita male [Consortial]FVB.B6-Ins2Akita/MlnJpancreas
Partially insulin-degranulated islet in FVB-Akita diabetic female [Consortial]FVB.B6-Ins2Akita/MlnJpancreatic islet
normal appearing islets in FVB-+/+ control male [Consortial]FVB/NJpancreas
normal appearing islet in FVB-+/+ control male [Consortial]FVB/NJpancreas
FVB-+/+ male control pancreas [Consortial]FVB/NJpancreas
FVB male wildtype control pancreas [Consortial]FVB/NJpancreatic islet
Normal appearing glomeruli, silver methenamine stain in FVB-+/+ male control [Consortial]FVB/NJkidney cortex
Normal appearing glomeruli in male FVB Akita male, silver methenamine stain [Consortial]FVB.B6-Ins2Akita/MlnJkidney cortex
FVB-+/Akita male [Consortial]FVB.B6-Ins2Akita/MlnJpancreas
FVB-+/Akita male [Consortial]FVB.B6-Ins2Akita/MlnJpancreas
FVB-+/Akita male [Consortial]FVB.B6-Ins2Akita/MlnJpancreas
silver methenamine [Consortial]129B6F1.Cg-Ins2Akita Nos3tm1Unc/Jkidney
silver methenamine [Consortial]129B6F1.Cg-Ins2Akita Nos3tm1Unc/Jkidney
Silver methenamine stained kidney [Consortial]129B6F1.Cg-Ins2Akita Nos3tm1Unc/Jkidney cortex
Normal glomeruli [Consortial]129B6F1.Cg-Nos3tm1Unc/Jkidney cortex
Glomerulus with ischemic changes [Consortial]129B6F1.Cg-Nos3tm1Unc/Jkidney cortex
Glomerular lesion [Consortial]129B6F1.Cg-Nos3tm1Unc/Jkidney cortex
Kidney cortex - one glomerulus with lesion [Consortial]129B6F1.Cg-Nos3tm1Unc/Jkidney
Kidney [Consortial]FVB.Cg-Ins2Akita Nr1h4tm1Gonz/Jkidney
FVB-FXRnull non-diabetic female control liver showing severe macrovesicular hepatosteatosis [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic female control liver showing ceroid-like pigment accumulation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic female control liver showing severe macrovesicular hepatosteatosis [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
Kidney cortex [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jkidney
Glomeruli with expanded mesangial matrix [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jkidney cortex
Interstitial inflammation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jkidney cortex
Kidney with patchy interstitial fibrosis [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jkidney
FVB-FXRnull non-diabetic control liver showing hepatosteatosis [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic male control liver with ceroid-like pigment in bile canaliculi [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic male control liver with ceroid-like pigment in bile canniculi [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic control liver showing widespread ceroid-like pigment [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic control liver showing focal macrovesicular hepatosteatosis [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic control liver showing ceroid-like pigment accumulation [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
FVB-FXRnull non-diabetic male control liver showing macrovesicular steatosis [Consortial]FVB.Cg-Nr1h4tm1Gonz/Jliver
One glomerulus with expanded mesangial matrix and mesangiolysis, others are normal [Consortial]D2.Cg-Ins2 Akita Nr1h4tm1Gonz/Jkidney cortex
Some glomeruli have expanded mesangial matrix and mesangiolysis [Consortial]D2.Cg-Ins2 Akita Nr1h4tm1Gonz/Jkidney cortex
Kidney cortex with focal interstitial fibrosis [Consortial]D2.Cg-Ins2 Akita Nr1h4tm1Gonz/Jkidney cortex
Glomeruli with expanded mesangial matrix [Consortial]D2.Cg-Ins2 Akita Nr1h4tm1Gonz/Jkidney cortex
Silver methenamine stained [Consortial]BTBR.V(B6)+/?/WiscJkidney
Silver methenamine stained [Consortial]BTBR.V(B6)-Lepob/WiscJkidney
Silver methenamine stained [Consortial]BTBR.V(B6)-Lepob/WiscJkidney
Kidney lesions - increased mesangial matrix [Consortial]BTBR.V(B6)-Lepob/WiscJkidney
Silver methenamine stained [Consortial]BTBR.V(B6)-Lepob/WiscJkidney
Silver methenamine stained [Consortial]BTBR.V(B6)-Lepob/WiscJkidney
Kidney cortex [Consortial](ALRFVB)F1+/+kidney cortex
Kidney cortex [Consortial](ALRFVB)F1+/+kidney cortex
Kidney cortex [Consortial](ALRFVB)F1+/+kidney cortex
Kidney cortex [Consortial](ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](ALRFVB)F1+/+kidney cortex
Kidney cortex [Consortial](ALRFVB)F1+/+kidney cortex
Kidney cortex [Consortial](ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](ALRFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](PWKFVB)F1+/+kidney cortex
Kidney cortex [Consortial](PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](PWKFVB)F1+/+kidney cortex
Kidney cortex [Consortial](PWKFVB)F1+/+kidney cortex
Kidney cortex [Consortial](PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](PWKFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ)kidney cortex
Kidney cortex [Consortial](NONFVB)F1+/+kidney cortex
Kidney cortex [Consortial](NONFVB)F1+/+kidney cortex
Kidney cortex [Consortial](NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJkidney cortex
Kidney cortex [Consortial](NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJkidney cortex
Kidney cortex [Consortial](NONFVB)F1+/+kidney cortex
Kidney cortex [Consortial](NONFVB)F1+/+kidney cortex
Kidney cortex [Consortial](NONFVB)F1-(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJkidney cortex
Silver methenamine stained [Consortial]D2.B6-Ins2Akita/MatbJkidney
Whole slide scan - Silver methenamine stain [Consortial]D2.B6-Ins2Akita/MatbJkidney
Heart mineralization in severely diabetic DBA/2-Akita male [Consortial]D2.B6-Ins2Akita/MatbJheart
Epicardial mineralization in severely diabetic DBA/2-Akita male [Consortial]D2.B6-Ins2Akita/MatbJheart
Kidney lesions in 6 month-old Akita male [Consortial]D2.B6-Ins2Akita/MatbJkidney
Kidney of 6 month Akita male [Consortial]D2.B6-Ins2Akita/MatbJkidney
Atrophic islets in pancreas of severely diabetic DBA/2-Akita male [Consortial]D2.B6-Ins2Akita/MatbJpancreatic islet
Pancreatic islet in severely diabetic DBA/2 Akita male [Consortial]D2.B6-Ins2Akita/MatbJpancreatic islet
Kidney from 26 wk old DBA/2-Akita male [Consortial]D2.B6-Ins2Akita/MatbJkidney
Silver methenamine stained kidney [Consortial]DBA/2Jkidney cortex



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